Microfluidic technology is undergoing unprecedented development in biomedical research and clinical diagnostics. As a revolutionary technology that integrates laboratory functions onto tiny chips, microfluidic systems can precisely manipulate fluids at nano-to-micro liter scales to achieve various functions including sample processing, separation, and detection.

However, as systems become increasingly miniaturized, temperature control - a seemingly basic yet critical parameter - has become exceptionally challenging.

Leveraging its extensive expertise in thermoelectric cooling technology, Huajing Co., Ltd has developed specialized Microfluidic Series temperature control solutions.

These products not only address the limitations of traditional temperature control methods in miniaturized scenarios but also provide unprecedented temperature precision and stability for biochip experiments.

Technical Analysis of HUAJING Microfluidic Series Products

1. Application Principles of Thermoelectric Cooling in Microfluidics

HUAJING Microfluidic Series products utilize semiconductor active cooling technology based on the Peltier Effect, achieving rapid heating and cooling through precise control of current direction and magnitude. Compared to traditional compressor-based refrigeration, HJ-TC's Series thermoelectric cooling devices offer these significant advantages:

• No moving parts: Eliminates mechanical vibration interference with microfluidic experiments

• Fast response: Temperature change rates up to 1°C/second

• Precise control: Temperature stability within ±0.1°C

• Miniature design: Volume only 1/10 of traditional cooling systems

2. Product Series Overview and Technical Specifications

The HJ-TC Microfluidic Series includes multiple products optimized for different application scenarios:

1. TE05-40XXEL Plate-to-Liquid Series: Designed specifically for microfluidic chip liquid cooling, with cooling power up to 40W and excellent temperature uniformity on contact surfaces

   

   
   

2. TEK8-050XEA Plate-to-Air Series: Suitable for open microfluidic chip environments, featuring integrated temperature sensors for closed-loop control

   
   

   
   

   

   
   

   
   

3. TE40-300XEP Liquid-to-Air Series: High-power version ideal for clustered temperature control in high-throughput microfluidic systems

All products can be paired with HJ's self-developed HJ-B03-PTC Temperature Controller for intelligent temperature management.

Critical Role of Active Temperature Control in Biochips

1. Precise Temperature Control for PCR Amplification

In microfluidic PCR chips, temperature control accuracy directly affects DNA amplification efficiency. HJ Microfluidic Series products can:

• Rapidly switch between three temperature zones: 94°C (denaturation), 55-65°C (annealing), and 72°C (extension)

• Maintain temperature fluctuations within ±0.2°C in each zone

• Achieve heating/cooling rates up to 5°C/second, significantly shortening PCR cycles

2. Stability Assurance for Protein Crystallization Experiments

Protein crystallization demands extremely high temperature stability. HUAJING's Liquid-to-Liquid Series products ensure stability through:

• Dual-liquid cooling design to eliminate temperature fluctuations

• High thermal conductivity materials for uniform temperature distribution

• Intelligent PID algorithms to compensate for environmental changes

3. Dynamic Temperature Regulation for Cell Culture

In organ-on-chip and cell culture applications, HJ-TC solutions provide:

• Precise control within physiological temperature ranges (4-42°C)

• Programmable temperature gradients to simulate in vivo microenvironments

• CO₂ incubator-compatible designs

HUAJING's Technological Innovations

1. 3D Structural Optimization

HUAJING's R&D team employs advanced CAE Thermal Simulation Analysis to optimize three-dimensional thermal fields in microfluidic cooling devices, ensuring:

• Minimized heat flow paths

• Reduced thermal resistance

• Maximized temperature distribution uniformity

2. Breakthroughs in Materials Science

• Use of high thermal conductivity ceramic substrates (AlN, ≥180W/mK)

• Nanoscale thermal interface materials filling micron-level gaps

• Corrosion-resistant titanium alloy liquid channels

3. Intelligent Control Algorithms

Integrated adaptive PID control algorithms feature:

• Automatic environmental temperature compensation

• Real-time response to load changes

• Historical data learning optimization

Industry Application Cases

1. Portable Molecular Diagnostic Devices

An IVD company developed POCT equipment using HJ's TE09-100XEA:

• Reduced traditional PCR instrument size by 80%

• Shortened detection time from 2 hours to 30 minutes

• Operates in field environments from -10°C to 40°C

2. Single-Cell Analysis Chip Systems

Research institutions using HJ's Microfluidic Series for single-cell sequencing platforms:

• Achieve precise single-cell capture and lysis

• Maintain temperature control accuracy of ±0.1°C

• Increased throughput to 1000 cells/hour

3. Organoid Culture Monitoring Systems

Organ-on-chip systems integrated with HUAJING's Temperature Control Platform Series:

• Multi-zone independent temperature control

• Dynamic simulation of physiological temperature rhythms

• Long-term culture stability up to 30+ days

Future Development Directions

Huajing Co., Ltd is committed to these technological breakthroughs:

1. Nanoscale Cooling Devices: Reducing cooling unit size to 100-micron level

2. Multi-Physics Field Coupling Control: Integrating temperature, flow rate, electric field and other parameter coordination

3. AI-Driven Intelligent Temperature Control: Utilizing machine learning to predict and optimize temperature curves

The Benchmark in Microfluidic Temperature Control

HUAJING Microfluidic Series temperature control solutions represent the highest application level of thermoelectric cooling technology in life sciences. Through continuous innovation and deep industry expertise, HJ is advancing microfluidic technology from laboratory research to clinical and industrial applications. Its products not only achieve internationally leading performance parameters but also demonstrate significant advantages in system reliability, environmental adaptability, and cost control, becoming indispensable components in biochip research.

For researchers and companies requiring microfluidic temperature control solutions, HJ-TC offers comprehensive services from standard products to customized development. Please contact our technical team or visit our /product-center for more information.

Contact Our Thermal Experts:

📞 +86 18575222950 (WeChat/WhatApps)

📧 EMAIL: sale02@hj-tc.com

🌐 Browse products: https://www.huajingtc.com (Huajing Cooling Solutions)

📍 Address: SHENZHEN 3/F No.5 Building,Yesun Pingshan Life and Health Technology Park, No. 19 Linhui Road,Pingshan District, Shenzhen, Guangdong,CN.

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